Revolution Plus is a monthly topical parasiticide for cats that provides broad-spectrum protection against six common parasites: fleas, ticks (including the black-legged tick, Gulf Coast tick, and American dog tick), heartworm, ear mites, roundworms, and hookworms. Manufactured by Zoetis, Revolution Plus combines two active ingredients — selamectin and sarolaner — to offer more comprehensive coverage than the original Revolution (selamectin alone).
Revolution Plus is one of the most widely prescribed parasite prevention products for cats in the United States, valued for its convenience as an all-in-one monthly application.
What Is Revolution Plus Used For?
Revolution Plus protects cats against the following parasites:
| Parasite | Protection Type |
|---|---|
| Fleas (Ctenocephalides felis) | Kills adult fleas; prevents flea eggs from hatching |
| Ticks (Ixodes scapularis, Amblyomma americanum, Dermacentor variabilis) | Kills black-legged (deer) ticks, Gulf Coast ticks, and American dog ticks |
| Heartworm (Dirofilaria immitis) | Prevents heartworm disease by killing larvae |
| Ear mites (Otodectes cynotis) | Treats and controls ear mite infestations |
| Roundworms (Toxocara cati) | Treats and controls intestinal roundworm infections |
| Hookworms (Ancylostoma tubaeforme) | Treats and controls intestinal hookworm infections |
This combination of coverage makes Revolution Plus one of the broadest-spectrum topical products available exclusively for cats. Many veterinarians recommend it as a single monthly treatment to simplify parasite prevention.
How Does Revolution Plus Work?
Revolution Plus contains two active ingredients with complementary mechanisms:
Selamectin
Selamectin is a macrocyclic lactone that works by disrupting nerve and muscle function in parasites through glutamate-gated chloride channels. It is absorbed through the skin and distributed throughout the body, providing systemic activity against heartworm larvae, fleas, ear mites, roundworms, and hookworms. Selamectin has been used safely in cats for over two decades in the original Revolution product.
Sarolaner
Sarolaner is an isoxazoline, a newer class of parasiticide that targets a different set of nerve receptors (GABA and glutamate-gated chloride channels) in fleas and ticks. The addition of sarolaner to Revolution Plus provides enhanced and faster flea kill as well as tick protection, which the original Revolution did not reliably offer.
Together, these two ingredients provide overlapping and complementary activity against a wide range of external and internal parasites.
Dosage
Revolution Plus is applied topically once monthly. Your veterinarian will recommend the correct product size based on your cat’s body weight.
| Cat Weight Range | Tube Size | Selamectin Content | Sarolaner Content |
|---|---|---|---|
| 2.8-5.5 lbs (1.25-2.5 kg) | Gold tube | 15 mg | 2.5 mg |
| 5.6-11 lbs (2.5-5.0 kg) | Orange tube | 30 mg | 5 mg |
| 11.1-22 lbs (5.0-10.0 kg) | Green tube | 60 mg | 10 mg |
Important notes:
- Revolution Plus is approved for cats and kittens 8 weeks of age and older, weighing at least 2.8 lbs (1.25 kg).
- Apply once every 30 days, year-round, for continuous protection.
- Your veterinarian may recommend a heartworm test before starting any heartworm preventive, including Revolution Plus.
- Do not use Revolution Plus on dogs. It is formulated exclusively for cats.
- Always follow your veterinarian’s specific recommendations for your cat.
How to Give Revolution Plus to Your Cat
Revolution Plus is a topical solution applied to the skin.
Application steps:
- Remove the tube from the packaging and hold it upright.
- Press the cap down firmly to puncture the seal, then remove the cap.
- Part the fur at the base of your cat’s skull (between the shoulder blades) to expose the skin.
- Apply the entire contents of the tube directly onto the skin in one spot. Avoid applying to the fur, as this reduces absorption.
- Do not rub the application site.
- Avoid touching the application site until it is dry (typically 2-4 hours).
- Do not bathe your cat or allow swimming for at least 2 hours after application.
Tips:
- Apply when your cat is calm or relaxed.
- Separate multiple cats after application until the product dries to prevent them from grooming each other at the application site.
- If you have trouble with application, ask your veterinary team for a demonstration.
Side Effects
Revolution Plus is generally well tolerated by most cats. The following side effects have been reported.
| Common Side Effects | Serious Side Effects (Contact Your Vet) |
|---|---|
| Mild hair loss at application site | Persistent vomiting or diarrhea |
| Temporary lethargy | Tremors, incoordination, or seizures |
| Mild skin irritation at application site | Excessive drooling or salivation |
| Decreased appetite (temporary) | Signs of allergic reaction (swelling, difficulty breathing) |
| Sudden behavioral changes |
Note on isoxazolines: The isoxazoline class of drugs (which includes sarolaner in Revolution Plus) carries an FDA class-wide warning regarding the potential for neurologic adverse events, including tremors, ataxia (incoordination), and seizures, in some animals. These events have been reported rarely. Cats with a history of seizures or neurologic disorders should be evaluated by a veterinarian before starting any isoxazoline-containing product. Consult your veterinarian about whether Revolution Plus is appropriate for your cat.
Drug Interactions
No specific drug interactions with Revolution Plus have been identified in product labeling. However, always inform your veterinarian about all medications, supplements, and other parasite prevention products your cat is currently receiving.
Do not use Revolution Plus concurrently with other topical flea/tick products unless specifically directed by your veterinarian, as combining topical parasiticides may increase the risk of adverse effects.
Contraindications
- Do not use on dogs (Revolution Plus is for cats only).
- Do not use on kittens under 8 weeks of age or weighing less than 2.8 lbs.
- Use with caution in cats with a history of seizures or neurologic disorders (due to the isoxazoline component).
- The safety of Revolution Plus in breeding, pregnant, or lactating cats has not been fully evaluated. Consult your veterinarian.
Storage
- Store at room temperature (59-86 degrees F / 15-30 degrees C).
- Keep tubes in their original sealed packaging until ready to use.
- Protect from light.
- Keep out of reach of children and pets.
Cost & Availability
Revolution Plus is a prescription medication available through veterinary clinics and authorized online veterinary pharmacies.
| Package Size | Approximate Cost |
|---|---|
| 3-month supply | $60-$90 |
| 6-month supply | $90-$130 |
| 12-month supply | $160-$240 |
- Prices vary by cat weight range, geographic location, and pharmacy.
- Some manufacturers offer rebates or loyalty programs. Ask your veterinarian or check the manufacturer’s website for current offers.
- No generic version of Revolution Plus is currently available.
- Pet insurance policies that cover preventive care may partially reimburse the cost.
When comparing costs, consider that Revolution Plus replaces the need for separate flea, tick, heartworm, ear mite, and deworming products, which may represent a net savings compared to purchasing multiple individual treatments.
FAQ
Q: What is the difference between Revolution and Revolution Plus? A: The original Revolution (selamectin only) protects against fleas, heartworm, ear mites, and some intestinal worms but does not provide reliable tick protection. Revolution Plus adds sarolaner, which provides effective tick kill and enhanced flea activity. If tick protection is important for your cat (especially cats with any outdoor access), Revolution Plus may be the more comprehensive choice. Discuss with your veterinarian.
Q: Does my indoor cat need Revolution Plus? A: Indoor cats can still be at risk for certain parasites. Fleas can enter homes on clothing, other pets, or through open doors. Heartworm is transmitted by mosquitoes, which can enter homes. Your veterinarian can help you assess your cat’s individual risk and recommend the most appropriate prevention plan.
Q: Can I use Revolution Plus on my dog? A: No. Revolution Plus is formulated and approved exclusively for cats. Dogs have different product options. Using the wrong species product can result in incorrect dosing and potential safety issues. Consult your veterinarian for dog-appropriate parasite prevention.
Q: What if my cat grooms the application site? A: Applying the product at the base of the skull (between the shoulder blades) minimizes the chance of self-grooming. If your cat does lick the site before it dries, mild salivation or brief GI upset may occur. Contact your veterinarian if you notice concerning symptoms.
Q: Does Revolution Plus protect against tapeworms? A: No. Revolution Plus does not treat or prevent tapeworm infections. If your cat has tapeworms (often seen as small rice-like segments near the tail or in stool), your veterinarian may prescribe praziquantel or another appropriate dewormer separately.
Sources & References
- FDA - Revolution Plus (Selamectin/Sarolaner) Approval Information
- Zoetis - Revolution Plus Product Information
- Merck Veterinary Manual - Flea and Tick Control
- VCA Animal Hospitals - Heartworm Disease in Cats
- American Heartworm Society - Heartworm Prevention for Cats
- FDA - Fact Sheet for Pet Owners about Isoxazoline Products
This content is for informational purposes only and is not a substitute for professional veterinary advice. Always consult your veterinarian to determine the best parasite prevention plan for your cat.