Cytopoint (lokivetmab) is a prescription injectable biologic therapy manufactured by Zoetis for the control of pruritus (itch) associated with atopic dermatitis and allergic skin disease in dogs. Unlike traditional antihistamines or immunosuppressants, Cytopoint is a caninized monoclonal antibody that specifically targets and neutralizes interleukin-31 (IL-31), a key cytokine involved in sending itch signals to the brain. Because it acts like a natural antibody rather than a conventional drug, Cytopoint does not require liver or kidney metabolism and has no known drug interactions. There is no minimum age or weight requirement, making it an option for puppies and dogs of all sizes.
What Is Cytopoint Used For?
Veterinarians prescribe Cytopoint for the management of:
- Atopic dermatitis (environmental allergies) causing chronic or seasonal itching
- Allergic pruritus that significantly impacts a dog’s comfort and quality of life
- Cases where oral medications are difficult to administer or cause unacceptable side effects
- Dogs that need rapid itch relief while a long-term allergy management plan is developed
Cytopoint controls the clinical signs of allergic itch but does not cure the underlying allergy. Your veterinarian may recommend it alongside other therapies such as allergen avoidance, medicated shampoos, fatty acid supplements, or immunotherapy. Consult your veterinarian to determine if Cytopoint is right for your dog.
Dosage
Cytopoint is administered as a subcutaneous injection by a veterinarian at a minimum dose of 2 mg/kg (0.9 mg/lb). Injections are typically given every 4 to 8 weeks, depending on your dog’s response.
| Dog’s Weight | Minimum Dose | Typical Injection Interval |
|---|---|---|
| Under 10 lbs | 2 mg/kg | Every 4-8 weeks |
| 10-20 lbs | 2 mg/kg | Every 4-8 weeks |
| 20-40 lbs | 2 mg/kg | Every 4-8 weeks |
| 40-80 lbs | 2 mg/kg | Every 4-8 weeks |
| Over 80 lbs | 2 mg/kg | Every 4-8 weeks |
Cytopoint is available in vials of 10 mg, 20 mg, 30 mg, and 40 mg. Your veterinarian will select the appropriate vial size(s) based on your dog’s weight. Some dogs experience relief for the full 4-8 weeks; others may need more frequent injections. Your veterinarian will tailor the schedule to your dog’s needs.
Side Effects
Cytopoint has a favorable safety profile because it mimics a natural canine antibody and is broken down through normal protein degradation pathways.
| Common Side Effects | Serious Side Effects (Contact Your Vet) |
|---|---|
| Mild lethargy (first 24-48 hrs) | Signs of allergic reaction (facial swelling, hives, difficulty breathing) |
| Minor injection site reaction | Severe vomiting or diarrhea after injection |
| Mild GI upset (uncommon) | Worsening skin infection |
Serious adverse reactions are rare. In clinical studies, side effect rates were similar between Cytopoint-treated dogs and placebo-treated dogs. Always report any unusual signs to your veterinarian following an injection.
Drug Interactions
Cytopoint has no known drug interactions. Because it is a biologic (monoclonal antibody) that is metabolized like a natural protein, it does not rely on the liver or kidneys for processing and does not interfere with cytochrome P450 enzymes. It can generally be used safely alongside other medications including:
- Apoquel (oclacitinib)
- Antibiotics
- Antifungals
- Flea/tick preventives
- Corticosteroids
Always inform your veterinarian of all medications and supplements your dog receives.
Contraindications
- Dogs with a known hypersensitivity to lokivetmab or any component of the product
- Cytopoint is not approved for cats
There is no minimum age or weight restriction. Cytopoint has been used in puppies and geriatric dogs. Use with caution in dogs with active infections, as reducing itch may mask signs of secondary skin infection. Your veterinarian will evaluate whether active infections need treatment before or alongside Cytopoint therapy.
Storage
- Store refrigerated at 35-46 degrees F (2-8 degrees C).
- Do not freeze.
- Protect from light.
- Cytopoint is administered in-clinic by a veterinarian; you do not need to store it at home.
Frequently Asked Questions
How quickly does Cytopoint work? Many dogs experience significant itch relief within 24 hours of injection, with full effect typically seen within the first few days. If itch returns before the next scheduled injection, consult your veterinarian about adjusting the interval.
Is Cytopoint safe for puppies? Yes. There is no minimum age requirement for Cytopoint. It has been safely used in puppies experiencing allergic itch. Your veterinarian will determine if it is appropriate for your puppy’s specific situation.
Can Cytopoint be used with Apoquel? Yes. Some veterinarians use both Cytopoint and Apoquel together in difficult-to-manage allergy cases, though most dogs are controlled with one or the other. Consult your veterinarian about the best approach for your dog.
Does Cytopoint suppress the immune system? No. Cytopoint specifically neutralizes IL-31, the itch cytokine. It does not broadly suppress the immune system the way corticosteroids or some other allergy medications do.
How much does Cytopoint cost? Cost typically ranges from $50 to $150 per injection depending on your dog’s size and your geographic area. Larger dogs require more product and therefore cost more per treatment.
This content is for informational purposes only and is not a substitute for professional veterinary advice. Always consult your veterinarian before starting, changing, or stopping any medication for your dog.